As a young man, Strupler worked as a window decorator by the Swiss fashion firm PKV. He later established himself as an artist known for his book illustrations and classical music album covers. Strupler was inspired by music (he loved Jazz), the works of Paul Klee, and the Hermann Hesse novel Siddhartha. He loved to travel and did so frequently, including trips to North Africa, India and Nepal. A leitmotif of his work is the Ferryman standing on the bow of his ship. Another favorite theme was the Mandala. He lived quietly and out of the public spotlight, dividing his time a studio in Tremona, where his grandparents had lived, und in Zürich's Spiegelgasse. (He called himself "The Hermit of Grimmenturm.") In addition to his lithography, he collaborated with his mother on tapestries of his work.
Hans Rudolf Strupler's work has been widely exhibited in Switzerland and around the world. Over 80 exhibits were held during his lifetime. He is listed in the Biographical Dictionary of Swiss Art, the Lexicon of Contemporary Swiss Artists and the Artists Lexicon of Switzerland.
Works by Hans Rudolf Strupler